Chromosomes, Dermatoglyphics and Polycystic Ovary Syndrome (pcos)
نویسنده
چکیده
Keywords: chromosomal dermatoglyphics genetics infertility Polycystic ovarian syndrome PCOS Original Article Aims: To study and co-relate chromosomal abnormalities and dermatoglyphics in infertile female patients with PCOS. Method: 16 cases of PCOS and 16 normal females as controls were selected. Chromosomal study was done using whole blood culture method and GTG Banding in genetic laboratory. Palmar and Plantar Dermatoglyphics were studied using " Roller ink method " using Kore's duplicating ink and analyzed using Henry's system. Result: Incidence of chromosomal abnormalities is 81.25% (13/ 16 cases). Distribution of chromosomal abnormalities is as follows. In dermatoglyphics, statistically significant findings are, absence of elliptical whorl pattern in finger tip patterns of both hands and absence of tibial loop in area V of ball region of left foot in patients as compared to controls. Conclusions: Absence of elliptical whorl pattern in finger tip patterns of both hands and tibial loop in area V of ball region of left foot in dematoglyphics while microdeletions (2)(q12);(10)(q25) in chromosomal study are significant findings in PCOS which are co-related and can be used as marker. Chromosomal abnormalities might be the cause of failures in ARTs in such cases. This would be of great help to infertility clinicians for screening and to get a guideline to decide line of treatment while to the patients to reduce psychosocial and financial stress during treatment.
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